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Novedades

Dictado de curso: "Rehabilitación Oral con Implantes"

Lab. Bioimplantes - Facultad de Ingeniería - Universidad Nacional de Entre Ríos

Se dictará próximamente el curso de "Rehabilitación Oral con Implantes".
Consultas: Dr. Oscar Decco (odecco@bioimplantes.com.ar) o Bioing. Jésica Zuchuat (jzuchuat@bioimplantes.com.ar)

Disertación del Dr. Od. Oscar Deccó en Simposio Taller de Bioeconomía:
Biomateriales, Desarrollos tecnlógicos de origen biológico

Paraninfo UNL - Ciudad de Santa Fe - 9 de noviembre

La actividad tuvo como objetivo informar acerca de las investigaciones desarrolladas por el Laboratorio de Bioimplantes, en el marco de la Región Centro, con el fin de generar espacios de articulación y debate sobre las tendencias a nivel nacional e internacional en biomateriales, haciendo hincapié en los desarrollos científicos y alternativas tecnológicas para el sector productivo.

Sitio del evento

bioeconomia

Exposición de poster "Fotofuncionalización de la alecaión de Cr-Co-Mo empleada en procedimientos de aumento óseo mediante radiación UV controlada"

Centro Científico y Tecnológico - La Plata - 1 y 2 de noviembre

Como una primera aproximación para determinar la afinidad existente entre la sangre y un biomaterial tratado superficialmente, en un medio biológico, se han desarrollado técnicas de cuantificación de la humectación a través de la medición del ángulo de contacto. Esta magnitud indica el grado de afinidad de un material por un líquido. Generalmente, se utiliza agua como medio líquido, obteniendo resultados similares a los que se producen con la sangre. La técnica de fotofuncionalización se utiliza para mejorar las propiedades superficiales de materiales implantables. En el titanio se han reportado buenos resultados en estudios in vitro, respecto a la proliferación y supervivencia celular, e in vivo en relación a la oseointegración de implantes, aunque sobre otros materiales de implante, como la aleación de CrCoMo no ha sido explorado en profundidad. Mediante el empleo de discos de CrCoMo granallados y envejecidos durante 8 semanas, se estudió el fenómeno de fotofuncionalización de la superficie con radiación UVA (365 nm) y UVC (254 nm), y se evaluó la bioactividad de estas mediante una incubación in vitro durante 7 días en líquido simulador de tejido biológico (RSBF). Se estudiaron la variación del ángulo de contacto pre y post irradiación, y la composición superficial de los discos cuantificando el porcentaje en peso de los cristales de Ca y P por el método EDAX ZAF mediante EDS. Se encontraron diferencias estadísticamente significativas, correspondiente a superficies hidrofílicas, para las muestras irradiadas con UVA durante 48 horas y para las irradiadas con UVC durante 3 horas, y se encontraron superficies superhidrofílicas para aquellas irradiadas durante 12, 24 y 48 horas con UVC. Se determinó que la disminución en el contenido de carbono se relaciona con el aumento en el contenido de calcio y fósforo, y viceversa sobre las superficies de CrCoMo.

Sitio del evento /// Otras publicaciones de laboratorio

poster

Se ha publicado el paper: "Improvement of Cr-Co-Mo Membrane Surface Used as Barrier for Bone Regeneration through UV Photofunctionalization: An In Vitro Study". Autores: Oscar Decco, Jésica Zuchuat, Nicolás Farkas.

Materials - Julio de 2017

Abstract: Although there are several studies of the ultraviolet (UV) light-mediated photofunctionalization of titanium for use as implant material, the underlying mechanism is not fully understood. However, the results of in vitro and in vivo studies are very encouraging. The use of UV photofunctionalization as a surface treatment on other implant materials, as the Cr-Co-Mo alloy, has not been explored in depth. Using sandblasted Cr-Co-Mo discs, the surface photofunctionalization was studied for ultraviolet A (UVA, 365 nm) and ultraviolet C (UVC, 254 nm), and the surfaces were evaluated for their ability to sustain hydroxyapatite crystal growth through incubation in simulated body fluid for a seven-day period. The variation of the pre- and post-irradiation contact angle and surface composition was determined through the quantification of the weight percentage of Ca and P crystals by the EDAX ZAF method (EDS). Statistically significant differences (p minor 0.05) were found for samples irradiated with UVA over 48 h, corresponding with hydrophilic surfaces, and the same result was found for samples exposed to 3 h of UVC. Superhydrophilic surfaces were found in samples irradiated for 12, 24 and 48 h with UVC. The decrease in the carbon content is related with the increase in the surface content of Ca and P, and vice versa over the Cr-Co-Mo surfaces.

Acceso a Meterials /// Descargar artículo completo /// Otras publicaciones de laboratorio

Se ha publicado el paper: "Localized tissue mineralization regulated by bone remodelling: a computational approach". Autores: Marcelo Berli, Carlos Borau, Oscar Decco, George Adams, Richard B. Cook, José Manuel García Aznar, Peter Zioupos.

PLOS ONE - Marzo de 2017

Abstract: Bone is a living tissue whose main mechanical function is to provide stiffness, strength and protection to the body. Both stiffness and strength depend on the mineralization of the organic matrix, which is constantly being remodelled by the coordinated action of the bone multicellular units (BMUs). Due to the dynamics of both remodelling and mineralization, each sample of bone is composed of structural units (osteons in cortical and packets in cancellous bone) created at different times, therefore presenting different levels of mineral content. In this work, a computational model is used to understand the feedback between the remodelling and the mineralization processes under different load conditions and bone porosities. This model considers that osteoclasts primarily resorb those parts of bone closer to the surface, which are younger and less mineralized than older inner ones. Under equilibrium loads, results show that bone volumes with both the highest and the lowest levels of porosity (cancellous and cortical respectively) tend to develop higher levels of mineral content compared to volumes with intermediate porosity, thus presenting higher material densities. In good agreement with recent experimental measurements, a boomerang-like pattern emerges when plotting apparent density at the tissue level versus material density at the bone material level. Overload and disuse states are studied too, resulting in a translation of the apparent–material density curve. Numerical results are discussed pointing to potential clinical applications.

Acceso a PLOS ONE /// Artículo completo /// Otras publicaciones de laboratorio

Se ha publicado el paper: "Conventional extraction vs. enucleation in anterior maxillary sites: a pilot study in humans". Autores: Oscar A. Decco, Jésica I. Zuchuat, Andrea C. Cura, Jorgelina A. Decco, Wilfried Engelke.

International Journal of Clinical and Experimental Medicine - Vol. 10 (2017)

Abstract: Background: Surgical extraction of ankylosed roots may cause severe defects of the alveolar crest. The aim of the present study was to determine the effects of flapless enucleation on the frequency of osteotomy and the maintenance of the alveolar crest width. Method: Ten patients (3 m, 7 f) requiring extractions in the anterior maxillary zone were included and randomly treated with conventional extraction and flapless microsurgical enucleation; osteotomy served as rescue technique in both groups. Socket preservation was performed using in situ hardening TCP bone substitute. Results: In the extraction group, 4/10 patients required osteotomy, in the enucleation group 0/10 (P minor 0.05, chi-square test). The alveolar widths 3 mm below the gingiva before surgery, at 3 and 6 months were 11.50, 8.98, and 9.50 mm in the extraction group and 12.25, 11.35, and 11.25 mm in the enucleation group, respectively. Two of 10 control sites and 0 of 10 test sites required augmentation for implant placement. Conclusion: Flapless enucleation combined with socket preservation appears to provide adequate maintenance of alveolar structures for implant placement and may be an alternative for surgical extraction in ankylosed anterior maxillary sites.

International Journal of Clinical and Experimental Medicine /// Artículo completo /// Otras publicaciones de laboratorio

Se ha publicado el paper "Minimally Invasive Technique For Transalveolar Sinus Floor Elevation with A Diamond Burr Used in Skull Base Surgery: A Case Series". Autores: Oscar A. Decco, Jésica I. Zuchuat, Ysaí Maldonado.

IOSR Journal of Dental and Medical Sciences - Diciembre de 2016

Abstract: When alveolar ridges lack the appropriate bone volume for implant placement, additional surgical procedures are necessary. In the posterior maxilla, the pneumatization of the maxillary sinus reduces the residual crestal height, and to perform implant placement, several sinus floor elevation techniques have been developed. These techniques involve specific instruments that require some experience, especially when performing sinus membrane lifting because of its importance for surgery success. A minimally invasive transalveolar sinus floor elevation technique is presented, in which a diamond burr used in cranial base surgery is employed. Surgery was performed on 10 patients. Panoramic radiographs and computerized tomography (CT) scans were taken before surgery and 1 month and 2 years after surgery, and they were used to measure bone height. The achieved augmentation heights were between 2.18 and 5.93 mm. All of the surgical procedures were conducted without complications. No Schneiderian membrane was perforated, and a vertical augmentation for allowing implant placement was achieved. It represent a good technique for minimally invasive sinus floor elevation.

IOSR Journal of Dental and Medical Sciences /// Otras publicaciones

Se ha publicado el capítulo: "Application of bioreactor concept and modeling techniques in bone regeneration and augmentation treatments." en el libro "Advanced Surfaces for Stem Cell Research". Autores: Decco O., Zuchuat J.

WILEY-ScrivenerPublishing - Julio de 2016

The book outlines first the importance of Extra Cellular Matrix (ECM), which is a natural surface for most of cells. In the following chapters the influence of biological, chemical, mechanical, and physical properties of surfaces in micro and nano-scale on stem cell behavior are discussed including the mechanotransduction. Biomimetic and bioinspired approaches are highlighted for developing microenvironment of several tissues, and surface engineering applications are discussed in tissue engineering, regenerative medicine and different type of biomaterials in various chapters of the book.

Chapter 10: Application of bioreactor concept and modeling techniques in bone regeneration and augmentation treatments.

Authors: Decco O., Zuchuat J. Editors: Ashutosh T., Bora G., Lokman U.

Índice del capítulo:
10.1 Bone Tissue Regeneration
10.2 Actual Therapeutic Strategies and Concepts to Obtain an Optimal Bone Quality and Quantity
10.3 Bioreactors Employed for Tissue Engineering in Guided Bone Regeneration
10.4 Bioreactor Concept in Guided Bone Regeneration and Tissue Engineering: In Vivo Application
10.5 New Multidisciplinary Approaches Intended to Improve and Accelerate the Treatment of Injured and/or Diseased Bone
10.6 Computational Modeling: An Effective Tool to Predict Bone Ingrowth


Acceso al libro - WILEY on line /// Otras publicaciones de laboratorio

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